Modulation of Feeding Through Pharmacological Targeting of the Relaxin-3 Receptor Rxfp3

Grant number: 1066369 | Funding period: 2014 - 2016

Completed

Abstract

Relaxin-3 is a neuropeptide that regulates a number of physiological processes, including food intake, suggesting that the relaxin-3 receptor RXFP3 may be a new target for treatment of eating disorders such as obesity. This project will develop new selective and high-affinity ligands for RXFP3, which will be critical pharmacological tools for the preclinical studies and evaluation of this system.

Related publications (3)

Binding conformation and determinants of a single-chain peptide antagonist at the relaxin-3 receptor RXFP3

LM Haugaard-Kedström, HS Lee, MV Jones, A Song, V Rathod, MA Hossain, RAD Bathgate, KJ Rosengren

2018-10-12

The neuropeptide relaxin-3 and its receptor relaxin family peptide receptor-3 (RXFP3) play key roles in modulating behavior such a..

Distinct but overlapping binding sites of agonist and antagonist at the relaxin family peptide 3 (RXFP3) receptor

LLL Wong, DJ Scott, MA Hossain, QK Kaas, J Rosengren, RAD Bathgate

2018-10-12

The relaxin-3 neuropeptide activates the relaxin family peptide 3 (RXFP3) receptor to modulate stress, appetite, and cognition. RX..

Development of a single-chain peptide agonist of the relaxin-3 receptor using hydrocarbon stapling

K Hojo, MA Hossain, J Tailhades, F Shabanpoor, LLL Wong, EEK Ong-Pålsson, HE Kastman, S Ma, AL Gundlach, KJ Rosengren, JD Wade, RAD Bathgate

2016-08-25

Structure-activity studies of the insulin superfamily member, relaxin-3, have shown that its G protein-coupled receptor (RXFP3) bi..

University of Melbourne Researchers

Ross Bathgate